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The authors believe that MRV will be a useful mouse model to study the impact of HHV-6 & 7 in humans.
Virologists led by Serge Barcy, Ph D at the Seattle Children’s Research Institute and University of Washington have identified a homolog for HHV-7 in pigtail macaques They were surprised to learn that it could be detected in the peripheral nerve ganglia, and hope to use their new animal model to explore how HHV-7 might play a role in demyelinating diseases.
HHV-6 was the most commonly reactivated virus, with 61% of patients affected patients .
“Off-the-shelf” donor T cells primed to fight five specific viruses were shown to be effective in a Phase 2 trial backed by Viracyte.
Branka Horvat, MD, Ph D, Director of Research at the International Centre for Infectiology Research in Lyon, France (INSERM), and her doctoral student Josephine Reynaud have recently published an important paper on a new transgenic mouse model Swedish investigators have found HHV-6 protein in the pancreatic islet cells of both type 1 diabetes patients and controls.
Investigators by at the University of Ferrara report intriguing alterations in intracellular regulation of HHV-6A-infected thyrocytes and T cells.
Swedish investigators have found HHV-6 protein in the pancreatic islet cells of both type 1 diabetes patients and controls.
Investigators at Fred Hutch Cancer Research Center found that HHV-6B is the first DNA virus to reactivate at a median of 3 weeks, compared to CMV, EBV and Adenovirus at 5-6 weeks.
HHV-6B also peaked rapidly, unlike other DNA viruses that took 3-6 weeks to reach peak viral load.
These ancient strains vary considerably from modern non-inherited strains of HHV-6A and appear just as likely to activate as their more modern cousins.
HIV patients on antiretrovrial therapy with high levels of HHV-6 shedding had lower levels of IL-6 and other inflammatory markers.
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HHV-6B reactivation resulted in increased mortality after 100 days.